Medical Systems Biology / Neurosciences

University Hospital Jena (UKJ) - Neurological Hospital

Otto Witte (Group Leader)

Focus on translational research on neurodegenerative diseases and ageing, fetal programming and transgenerational effects of stress and inflammation and sepsis. The group currently coordinates a EU-funded collaborative project (STREP, FP6) on system biology of ageing (ARGES: age-dependent inflammatory responses following stroke). We collected data (blood and brain samples) from more than 3000 mice of different ages (up to 24 months) in several experimental groups for transcriptomics, proteomics and metabolomics.

For more information look at the Medical Systems Biology Group pages of the University Hospital Jena (UKJ).

Selected Publications

• Schmidt S, Redecker C, Bruehl C, Witte OW:
  Age-related decline of functional inhibition in rat cortex.
  Neurobiol Aging. 2010; 31:504-11.
• Sieber MW, Guenther M, Kohl M, Witte OW, Claus RA, Frahm C:
  Inter-age variability of bona fide unvaried transcripts. Normalization of quantitative PCR data in ischemic stroke.
  Neurobiol Aging. 2010; 31:654-64.
• Urbach A, Redecker C, Witte OW:
  Induction of neurogenesis in the adult dentate gyrus by cortical spreading depression.
  Stroke. 2008; 39:3064-72.
• Bauer M, Huse K, Settmacher U, Claus RA:
  The heme oxygenase-carbon monoxide system: regulation and role in stress response and organ failure.
  Intensive Care Med. 2008; 34:640-8.
• Frasch MG, Müller T, Wicher C, Weiss C, Löhle M, Schwab K, Schubert H, Nathanielsz PW, Witte OW, Schwab M:
  Fetal body weight and the development of the control of the cardiovascular system in fetal shee.
  J Physiol. 2007; 579:893-907.