Systems Biology / Bioinformatics

Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI)

Reinhard Guthke (Group Leader)

Bioprocess data analysis and modelling of microbiological and clinical processes with focus on time series, transcriptome and proteome data analysis and network inference to generate hypotheses for dynamic modelling. The group is actively involved in several Systems Biology and Bioinformatics Initiatives, such as the Jena Centre for Bioinformatics (JCB) and the German Systems Biology Initiatives HepatoSys and FORSYS-Partner, and also in industry projects.

For more information look at the Systems Biology / Bioinformatics Group page of the Hans Knöll Institute (HKI).

Selected Publications

• Albrecht D, Guthke R, Brakhage AA, Kniemeyer O:
  Integrative analysis of the heat shock response in Aspergillus fumigatus.
  BMC Genomics. 2010; 11:32.
• Albrecht D, Kniemeyer O, Brakhage AA, Guthke R:
  Missing values in gel-based proteomics.
  Proteomics. 2010; 10:1202-11.
• Hecker M, Goertsches RH, Engelmann R, Thiesen HJ, Guthke R:
  Integrative modeling of transcriptional regulation in response to antirheumatic therapy.
  BMC Bioinformatics. 2009; 10:262.
• Hecker M, Lambeck S, Toepfer S, van Someren E, Guthke R:
  Gene regulatory network inference: data integration in dynamic models - a review.
  BioSystems. 2009; 96:86-103.
• Guthke R, Zeilinger K, Sickinger S, Schmidt-Heck W, Büntemeyer H, Iding K, Lehmann J, Pfaff M, Pless G, Gerlach JC:
  Dynamics of amino acid metabolism of primary human liver cells in 3D bioreactors.
  Bioprocess Biosyst Eng. 2006; 28:331-40.